Serie A Matchday 4 kicks off tonight at 8:45 PM with Lecce-Cagliari and concludes Monday with Napoli-Pisa. The highlight of the weekend, however, remains the Rome derby, a timeless Italian classic.
Here’s our recommended lineup for this round. Among certainties, surprises, and a few gambles, these are the players who can make the difference in fantasy football.
FORMATION: 3-4-3
Goalkeeper
The Rome derby is a special match, often decided by episodes. Sarri’s Lazio create plenty of chances but often fail to finish: this is why the Giallorossi goalie could make a number of saves that will be useful, and who knows, maybe even a clean sheet!

Difensori
Verona has historically been a tough opponent for Juventus, but Cambiaso already demonstrated two seasons ago that he can be a decisive factor in this tie. His ability to get forward and create dominance on the flanks makes him an intriguing choice.

In addition to being a rock-solid defender and reliable in duels, Baschirotto has now become a true icon of Italian fantasy football: a “living meme” who combines defensive solidity and potential for bonus set pieces.

A valuable winger in Italiano’s rotations. He faces a Genoa side that tends to struggle on the wings. His runs can lead to dangerous crosses and, with a bit of luck, even a crucial bonus assist.

Centrocampisti
No longer a surprise, he’s a true cornerstone of Como. He supports the offensive play and manages the game with quality and vision.

He’s often the man who changes AC Milan’s games. He’ll start in Udine. His acceleration and ability to make an impact in the final minutes always make him a desirable option.

Is there any real need for motivation? KDB should always be fielded, especially against a newly promoted team.

He’s undoubtedly the technical leader of the Ducali, with well-trained feet and the ability to make decisions from a standing start. If you’re into more exotic names, he’s a great fit.

Attaccanti
Having arrived at Cagliari with high expectations after his season at Empoli, Esposito is under scrutiny. He wants to prove he’s an undisputed starter and can make an impact right away.

He’s not in his best form, but that’s precisely why the match against Sassuolo could be a turning point. Inter’s captain remains a near-obligatory presence: often, when he seems to be struggling, he finds a way to break free.

The Montenegrin striker is looking for his first goal of the season for Inter. The match against Torino isn’t an easy one on paper, but the club is banking heavily on him.
